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Novel colloidal nanoparticles: physico-chemical characterization and interaction with lipid membranes

As a part of an ongoing large project on nanogels for topical drug delivery via the skin, the present project is focusing on the study of evaluations of physicochemical characteristics of novel polymeric nanoparticles and their interactions with lipids. It is proposed based on the common agreement that stratum corneum (SC) is the main barrier for percutaneous delivery of therapeutics.

In this project, nanogels (figure 1) are examined as novel drug carriers for TDDs (Transdermal Drug Delivery System) and are synthesized with the method of high dilution free radical polymerisation using a variety of monomers and cross-linkers. The nanogels preparations and their interactions with lipid layers will be analysed using different techniques including Zetasizer, Tensiometer, SEM (Scanning Electron Microscopy), TEM (Transmission Electron microscopy), QCM (Quartz Crystal Microbalance) and SANS (Small Angle Neutron Scattering). The aim is to understand the physicochemical characteristics of TDDs that lead to high permeability and thereby hopefully to improve the permeability and efficiency of TDDS.

Figure 1

Figure 1: nanogels formulation (a) during polymerization and (b) after drying: the powdery state allows long shelf-life and easy re-suspension in appropriate solvents

References
F. Brandl, F. Sommer, A. Goepferich, Rational design of hydrogels for tissue engineering: impact of physical factors on cell behaviour, Biomaterials, 28 (2006) 134-146
H. Bysell, R. Månsson, P. Hansson, M. Malmsten, Microgels and microcapsules in peptide and protein drug delivery, Advanced Drug Delivery Reviews, 63 (2011) 1172-1185
B. Baroli, Penetration of nanoparticles and nanomaterials in the skin: fiction or reality? Journal of Pharmaceutical Sciences, 99 (2010) 21-50
R.V. Alasino, V. Leonhard, I.D. Bianco, D.M. Beltramo, Eudragit E100 surface activity and lipid interactions, Colloids and Surfaces B: Biointerfaces, 91 (2012) 84– 89


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