Stimuli-responsive nanoparticles as novel topical drug delivery systems
This project aims to develop new stimuli-responsive nanoparticles (SRNís) reacting to changes in temperature and pH, and to evaluate their applications for both topical and transdermal drug delivery. New multifunctional materials will be prepared to obtaine nanoparticles using a combination of welldesigned monomers and biopolymers. These will be fully characterized and their application for transdermal drug delivery will be studied. Different preparation techniques will be used to generate nanoparticle with different physicochemical characteristics. Their clinical potential will be evaluated using preclinical in vitro skin models. These stimuli responsive nanoparticles may be characterized as an innovative approach to the development of new multifunctional skin delivery systems allowing the drug to be released, only when the tissue itself give the appropriate message, in terms of temperature and/or pH response.
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N. Sanoj Rejinold, P.R. Sreerekha, K.P. Chennazhi, S.V. Nair, R. Jayakumar, International Journal of Biological Macromolecules, 2011, 49, 161-172.
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